Table 1 Normal weight obesity (NWO) and incident postmenopausal breast cancer by subgroups in the UK Biobank.
Subgroups | No. of participants | NWL | NWO | P-interactiona |
|---|---|---|---|---|
Age | 0.702 | |||
<60 years | 24,072 | 1.00 | 1.15 (0.98–1.34) | |
≥60 years | 28,434 | 1.00 | 1.22 (1.07–1.38) | |
Ethnic | 0.715 | |||
White | 50,526 | 1.00 | 1.19 (1.08–1.32) | |
Others | 1980 | 1.00 | 1.04 (0.59–1.80) | |
Smoking status | 0.309 | |||
Never | 31,631 | 1.00 | 1.21 (1.06–1.38) | |
Ever | 16,299 | 1.00 | 1.19 (1.00–1.40) | |
Current | 4428 | 1.00 | 1.08 (0.77–1.51) | |
Drinking status | 0.304 | |||
Never | 2591 | 1.00 | 1.46 (0.91–2.34) | |
Ever | 1626 | 1.00 | 1.04 (0.60–1.82) | |
Current | 48,243 | 1.00 | 1.17 (1.06–1.30) | |
Physical activity | 0.396 | |||
Low | 5621 | 1.00 | 1.33 (1.01–1.74) | |
Medium | 17,713 | 1.00 | 1.08 (0.92–1.28) | |
High | 18,052 | 1.00 | 1.21 (1.01–1.45) | |
Educational level | 0.927 | |||
College or University degree | 18,270 | 1.00 | 1.14 (0.96–1.36) | |
A/AS levels or equivalent | 6122 | 1.00 | 1.24 (0.95–1.64) | |
O levels/GCSEs or equivalent | 11,741 | 1.00 | 1.14 (0.94–1.40) | |
Others | 11,5577 | 1.00 | 1.28 (1.00–1.45) | |
Townsend Deprivation Index | 0.780 | |||
Low | 17,483 | 1.00 | 1.20 (1.03–1.40) | |
Intermediate | 17,479 | 1.00 | 1.33 (1.13–1.58) | |
High | 17,486 | 1.00 | 1.00 (0.82–1.22) | |
Polygenic risk score | 0.027 | |||
Low | 17,019 | 1.00 | 1.11 (0.87–1.42) | |
Intermediate | 17,019 | 1.00 | 1.06 (0.87–1.28) | |
High | 17,024 | 1.00 | 1.32 (1.13–1.48) | |
History of mammograms | 0.855 | |||
Yes | 49,797 | 1.00 | 1.17 (1.06–1.29) | |
No | 2679 | 1.00 | 1.64 (0.93–2.87) | |
HRT use | 0.358 | |||
Yes | 23,980 | 1.00 | 1.21 (1.06–1.40) | |
No | 28,409 | 1.00 | 1.15 (1.00–1.32) | |
Number of births | 0.743 | |||
Nulliparous | 9594 | 1.00 | 1.21 (0.96–1.52) | |
<3 | 30,934 | 1.00 | 1.14 (1.00–1.29) | |
≥3 | 11,978 | 1.00 | 1.33 (1.07–1.66) | |
Age at menarche, years | 0.448 | |||
<12 | 9370 | 1.00 | 1.21 (0.96–1.53) | |
12–13 | 22,437 | 1.00 | 1.24 (1.07–1.45) | |
≥14 | 20,669 | 1.00 | 1.12 (0.96–1.31) | |
Age at menopause, years | ||||
<50 | 20,840 | 1.00 | 1.30 (1.10–1.53) | 0.772 |
50–55 | 24,969 | 1.00 | 1.09 (0.95–1.26) | |
≥55 | 6687 | 1.00 | 1.26 (0.99–1.61) |
