Table 2 Mucinous differentiation in relation to patient survival.

From: Associations of mucinous differentiation and mucin expression with immune cell infiltration and prognosis in colorectal adenocarcinoma

  

Colorectal cancer-specific survival

Overall survival

 

No. of cases

No. of events

Univariable HR (95% CI)

Multivariable HR (95% CI)

No. of events

Univariable HR (95% CI)

Multivariable HR (95% CI)

All patients

       

Mucinous differentiation

1049

292

  

525

  

 0%

668

178

1 (referent)

1 (referent)

317

1 (referent)

1 (referent)

 1–50%

296

86

1.14 (0.88–1.48)

0.99 (0.76–1.30)

158

1.20 (0.99–1.45)

1.00 (0.82–1.22)

 >50%

85

28

1.36 (0.91–2.02)

1.35 (0.89–2.04)

50

1.39 (1.03–1.87)

1.34 (0.98–1.82)

Ptrend

  

0.099

0.317

 

0.010

0.178

MMR-proficient

       

Mucinous differentiation

889

263

  

444

  

 0%

619

169

1 (referent)

1 (referent)

292

1 (referent)

1 (referent)

 1–50%

211

69

1.29 (0.97–1.70)

1.00 (0.75–1.33)

111

1.22 (0.98–1.51)

0.97 (0.78–1.22)

 >50%

59

25

1.87 (1.23–2.84)

1.36 (0.88–2.11)

41

1.80 (1.30–2.50)

1.32 (0.94–1.85)

Ptrend

  

0.002

0.332

 

0.0004

0.311

MMR-deficient

       

Mucinous differentiation

160

29

  

81

  

 0%

49

9

1 (referent)

1 (referent)

25

1 (referent)

1 (referent)

 1–50%

85

17

1.01 (0.45–2.27)

1.34 (0.50–3.57)

47

1.04 (0.64–1.68)

1.00 (0.56–1.77)

 >50%

26

3

0.54 (0.15–2.00)

1.55 (0.35–6.75)

9

0.61 (0.29–1.31)

0.93 (0.40–2.17)

Ptrend

  

0.442

0.506

 

0.304

0.887

  1. CI confidence interval, HR hazard ratio, MMR mismatch repair.
  2. Multivariable Cox proportional hazards regression models were adjusted for sex (male, female), age (< 65, 65–75, and >75 years), year of operation (2000–2005, 2006–2010, and 2011–2015), tumour location (proximal colon, distal colon, and rectum), stages (I–II, III and IV), tumour grade (low-grade or high-grade), lymphovascular invasion (negative or positive), MMR status (proficient or deficient), and BRAF status (wild-type or mutant). Ptrend values were calculated by using the categories of mucinous differentiation as continuous variables in Cox regression models.