Table 1 Baseline characteristics.

From: First-in-human phase I study of EMB-02, a bispecific antibody targeting PD-1 and LAG-3 in patients with advanced solid tumors

Demographics and baseline characteristics

Overall patients (N = 47)

Median age (range), years

61 (37–83)

Female; n(%)

28 (59.6)

Race [n (%)]

 Black or African American

2 (4.3)

 Asian

10 (21.3)

 Native Hawaiian or Other Pacific Islander

1 (2.1)

 White

34 (72.3)

ECOG PS; n(%)

 0

31 (66)

 1

16 (34)

Median Time Since Initial Diagnosis(range), years

2.11 (0.3–14.4)

Tumor type; n(%)

 Melanoma

12 (25.5)

 Colorectal cancer

10 (21.3)

 Non-small cell lung cancer

4 (8.5)

 Triple negative breast cancer

3 (6.4)

 Esophageal squamous cell carcinoma

3 (6.4)

 Gastric cancer

3 (6.4)

 Other

12 (25.5)

Prior CPI therapy; n (%)

20 (42.6)

 anti-PD-(L)1 only

18 (38.3)

 anti-PD-(L)1+anti-CTLA-4

2 (4.3)

Prior cancer-related surgery; n (%)

41 (87.2)

Prior radiotherapy; n (%)

32 (68.1)

Prior lines of systemic therapy; n (%)

 0

1 (2.1)

 1–2

25 (53.2)

 ≥3

21 (44.7)