Table 2 Multivariate logistic regression analysis of test results related to CIN2+ and CIN3+.

From: The triage role of cytological DNA methylation in women with non-16/18, specifically genotyping high-risk HPV infection

 

Total (N = 643)

n for CIN2+

OR(95%CI)

P value

n for CIN3+

OR (95%CI)

P value

LBC≥ASCUS

398

89

2.43 (1.23–4.81)

0.01

39

2.55 (1.25–5.21)

0.318

CISCER(+)

112

86

51.04 (27.15–95.94)

<0.001

44

68.07 (26.09–177.57)

<0.001

HPV31(+)

47

12

1.56 (0.53–4.59)

0.419

5

1.49 (0.56–3.97)

0.945

HPV33(+)

41

20

3.45 (1.21–9.82)

0.02

10

4.66 (2.13–10.19)

0.568

HPV35(+)

17

6

5.97 (1.36–26.25)

0.018

2

1.64 (0.36–7.40)

0.981

HPV39(+)

53

4

0.78 (0.2–3.08)

0.722

1

0.22 (0.03–1.61)

0.569

HPV45(+)

9

4

2.71 (0.37–19.84)

0.326

2

3.57 (0.72–17.66)

0.64

HPV51(+)

78

8

0.84 (0.29–2.44)

0.747

3

0.45 (0.14–1.49)

0.681

HPV52(+)

199

38

1.31 (0.64–2.69)

0.463

17

1.20 (0.65–2.22)

0.978

HPV56(+)

77

10

1.35 (0.5–3.67)

0.559

3

0.46 (0.14–1.51)

0.8

HPV58(+)

140

30

1.7 (0.78–3.7)

0.18

14

1.49 (0.78–2.85)

0.632

HPV59(+)

42

4

1.08 (0.3–3.97)

0.903

2

0.59 (0.14–2.51)

0.654

HPV66(+)

63

2

0.29 (0.06–1.49)

0.14

0

0.00 (0.00–Inf)

0.99

HPV68(+)

41

2

0.21 (0.03–1.27)

0.088

0

0.00 (0.00–Inf)

0.991

  1. Bold indicates P < 0.05.
  2. 95% CI 95% confidence interval, CISCER(+) ΔCt PAX1 ≤ 6.6 or ΔCt JAM3 ≤ 10.0, LBCASCUS Liquid-based cytology indicative of atypical squamous cells of undetermined significance or worse; OR odds ratio.