Fig. 5: Proteomic evaluation of DRG from treated mice.
From: Chemotherapy-induced neuropathy in monomethyl Auristatin E treatment: prevention by lithium
a Schematic representation of the protocol used for the proteomic assay. b Mean protein levels in DRG from LiCl, MMAE and LiCl+MMAE groups in comparison to the control divided into functional groups: Ca2+-Related proteins, proteins related to Inflammation and Tissue Damage and proteins that are linked to Nerve Damage and Repair (n = 5 animals each group). Proteins from the classic pathological mechanism of paclitaxel are also presented, with no significant alterations caused by MMAE or lithium treatments (p > 0.05).
