Table 1 Patient baseline, treatment, and sequencing characteristics by cohort
From: The colorectal liver metastasis growth pattern phenotype is not dependent on genotype
MSKCC | New EPOC | |||||||
|---|---|---|---|---|---|---|---|---|
missing (%) | n = 308 (%) | n = 153 (%) | p-value | 308 | 153 | |||
Age at resection of CRLM - (median [IQR]) | 54.0 [46.0, 63.0] | 64.0 [59.0, 69.0] | <0.001 | 0 | ||||
Gender | Male | 185 (60) | 104 (68) | 0.10 | 0 | |||
Female | 123 (40) | 49 (32) | ||||||
Primary tumour location | Right-sided | 21 (5) | 77 (27) | 30 (20) | 0.06 | 4.6 | ||
Left-sided | 124 (43) | 61 (40) | ||||||
Rectal | 86 (30) | 62 (41) | ||||||
T-stage | pT 0-2 | 24 (5) | 47 (16) | 16 (11) | 0.15 | 5.2 | ||
pT 3-4 | 244 (84) | 130 (89) | ||||||
N-stage | N0 | 24 (5) | 94 (32) | 47 (32) | 0.96 | 5.2 | ||
N + | 198 (68) | 98 (68) | ||||||
Number of CRLM - (median [IQR]) | 6 (1) | 2 [1,5] | 2 [1,3] | <0.001 | 1.3 | |||
Diameter of largest CRLM in cm - (median [IQR]) | 15 (3) | 2.5 [1.7, 4.2] | 1.9 [1.2, 3.3] | <0.001 | 3.3 | |||
Disease-free interval in monthsa - (median [IQR]) | 2 (0) | 0 [0, 5] | 1 [0, 13] | <0.001 | 0.4 | |||
Preoperative CEA in µg/L - (median [IQR]) | 31 (7) | 9.8 [3.8, 64.4] | 12.9 [4.5, 34.0] | 0.68 | 6.7 | |||
Perioperative systemic chemotherapy | No | 2 (0) | 25 (8) | 0 (0) | <0.001 | 0.4 | ||
Yes | 281 (92) | 153 (100) | ||||||
Resection margin involved | No | 7 (2) | 254 (83) | 118 (79) | 0.29 | 1.5 | ||
Yes | 51 (17) | 31 (21) | ||||||
Extrahepatic disease | No | 236 (77) | 149 (97) | <0.001 | 0 | |||
Yes | 72 (23) | 4 (3) | ||||||
Growth pattern phenotype | Non-encapsulated | 246 (80) | 111 (73) | 0.08 | 0 | |||
Encapsulated | 62 (20) | 42 (27) | ||||||
Origin of sequenced sample | CRLM | 157 (51) | 142 (93) | <0.001 | 0 | |||
CRC | 151 (49) | 11 (7) | ||||||
Average coverage depth - (median [IQR]) | 714.0 [593.5, 843.5] | 585.9 [477.2, 653.6] | <0.001 | 0 | ||||
Mutations per megabase - (median [IQR]) | 5.1 [3.6, 6.5] | 6.1 [4.6, 9.1] | <0.001 | 0 | ||||
