Fig. 1: Targeting ribosome alters the TME.
From: Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy
a Schematic showing therapy experiments of CX-5461 administration in tumor murine models. b, c UMAP plots showing cell types (b) and treatment groups (c) of CX-5461 administrated tumor murine models. d Polysome fractionation assays of CT26 cells extract without or with CX-5461 administration. e, f Dotplot showing expressions of cytotoxic granules in T (e) and NK (f) cells of CX-5461 administrated murine models. Dot size indicates proportion of cells expressing genes, dot color indicates mean expression of genes. g Dotplot showing expressions of TAM transcriptional states marker in macrophage of CX-5461 administrated tumor murine models. h Immunostaining of misfolded proteins marker PROTEOSTAT (green) and cytoskeleton marker Phalloidin (red) in CT26 cells upon CX-5461 treatment. Scale bar =10 µm.
