Fig. 4: Ribosome-targeting therapy-sensitive T cells are essential to immunotherapy efficacy.
From: Targeting ribosomes reprograms the tumour microenvironment and augments cancer immunotherapy
a UMAP plots showing T cell subtypes grouped by pre- and post-treatment of ICB in cases with lung cancer. b Boxplots showing T cells and each subtype cellular ribosome biogenesis grouped by pre- and post-treatment of ICB in cases with lung cancer. c Pseudo immunofluorescence based on UMAP plots showing cellular ribosome biogenesis (left), CD8+ T cell stress response state (middle) and FOXP3 (right) within T cells marked by pre- and post-treatment of ICB in cases with lung cancer. d–f Similar to (a–c), but in ICB treatment cases with CRC.
