Table 3 The diagnostic performance of FIT at 10, 20, 30, 40, 50, 75, and 100 μg Hb/g for patients aged 18–29 years, 30–39 years, and 18–39 years.

From: The diagnostic accuracy of the faecal immunochemical test for the detection of early-onset colorectal cancer: an age-stratified analysis in South West England

18–29 years

Threshold, μg Hb/g

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV, % (95% CI)

NPV, % (95% CI)

10

100 (29.2–100)

86.1 (85.1–87.0)

0.4 (0.1–1.3)

100 (99.9–100)

20

100 (29.2– 100)

88.9 (88.0– 89.8)

0.6 (0.1–1.6)

100 (99.9–100)

30

100 (29.2–100)

90.3 (89.4–91.1)

0.6 (0.1–1.9)

100 (99.9–100)

40

100 (29.2–100)

91.3 (90.4–92.1)

0.7 (0.1–2.1)

100 (99.9–100)

50

100 (29.2–100)

91.8 (91.0–92.5)

0.8 (0.2–2.2)

100 (99.9–100)

75

66.7 (9.4–99.2)

92.8 (92.1–93.6)

0.6 (0.1–2.1)

100 (99.9–100)

100

66.7 (9.4–99.2)

93.4 (92.7–94.1)

0.6 (0.1–2.3)

100 (99.9–100)

30–39 years

10

88.9 (65.3–98.6)

88.5 (87.9–89.1)

1.2 (0.7–1.9)

100 (99.9–100)

20

83.3 (58.6–96.4)

91.1 (90.5–91.6)

1.4 (0.8–2.3)

100 (99.9–100)

30

77.8 (52.4–93.6)

92.4 (91.9–92.9)

1.6 (0.9–2.6)

100 (99.9–100)

40

77.2 (46.5–90.3)

93.3 (92.8–93.7)

1.6 (0.9–2.8)

100 (99.9–100)

50

66.7 (41.0–86.7)

93.8 (93.3–94.2)

1.6 (0.8–2.8)

99.9 (99.9–100)

75

61.1 (35.7–82.7)

94.8 (94.4–95.2)

1.8 (0.9–3.1)

99.9 (99.9–100)

100

61.1 (35.7–82.7)

95.3 (94.9–95.7)

2.0 (1.0–3.5)

99.9 (99.9–100)

18– 39 years

Threshold, μg Hb/g

Sensitivity

Specificity

PPV

NPV

10

90.5 (69.6–98.8)

87.8 (87.3–88.3)

0.9 (0.6–1.5)

100 (99.9–100)

20

85.7 (63.7–97.0)

90.4 (90.0–90.9)

1.1 (0.7–1.8)

100 (99.9–100)

30

81.0 (58.1–94.6)

91.8 (91.4–92.2)

1.2 (0.7–2.0)

100 (99.9–100)

40

76.2 (52.8–91.8)

92.7 (92.3–93.1)

1.3 (0.8–2.1)

100 (99.9–100)

50

71.4 (47.8–88.7)

93.2 (92.8–93.6)

1.3 (0.7–2.2)

100 (99.9–100)

75

61.9 (38.4–81.9)

94.2 (93.8–94.6)

1.3 (0.7–2.3)

99.9 (99.9–100)

100

61.9 (38.4–81.9)

94.8 (94.4–95.1)

1.5 (0.8–2.5)

99.9 (99.9–100)

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