Fig. 1: Metabolite set enrichment analysis (MSEA) by class of metabolites (n = 218) for overall breast cancer incidence, Nurses’ Health Study II (1996–2011).
Stars denote P values adjusted by FDR: *Padj < 0.2; **Padj < 0.05; ***Padj < 0.001. Darker blue represents a more negative enrichment score (inverse association with breast cancer); darker red represents a more positive enrichment score (positive association with breast cancer). Model 1: Unadjusted conditional logistic regression model; Model 2: Model 1+ BMI at age 18, weight change (from age 18 to time of first blood draw); Model 3: Model 2+ age at menarche, parity and age at first birth, breastfeeding history, family history of breast cancer in a first degree relative, personal history of benign breast disease, physical activity, alcohol intake (by quintile), and oral contraceptive use at blood collection. DB double bound, FDR false discovery rate.
