Fig. 3: Chromatin accessibility changes between SKBR3 and SKBR3-L cell lines.

a Volcano plot of differentially accessible regions with the top 30 significant regions labelled by gene, with log2fold change < −2, adjusted p value < 0.05 (purple). Upregulated regions are shown with log2fold change > 2, adjusted p value < 0.05 (green). b Hierarchical clustered heatmap of the top 30 significantly differentially expressed regions identified by gene. c Transcription factor enrichment motif analysis. Top 30 significant hits (adjusted p value < 1e-52) identified motifs and the transcriptional factors that bind to the region. d Comparison by chromosome of SKBR3 SKBR3-L cell lines. Hyper-accessible regions (log2fold change > 2, adjusted p value < 0.05) and hypo-accessible regions (log2fold change < −2, adjusted p value < 0.05) are plotted on the bar graph. e Candidate regions within 6 bp from the TSS of nine different markers between SKBR3 and SKBR3-L cells. SKBR3 (red), SKBR3-L (blue).