Table 1 Univariate and multivariate analyses for overall survival in PDAC patients.

From: Inhibition of C5a-C5aR1 axis suppresses tumour progression by enhancing antitumour immunity and chemotherapeutic effect in pancreatic ductal adenocarcinoma

 

Total (n = 130)

Univariate analysis

Multivariate analysis

Hazard ratio (95% CI)

p value

Hazard ratio (95% CI)

p value

Age (years) (65≦65)

100/30

1.50 (0.83–2.70)

0.17

  

Gender (male/female) 

64/66

1.22 (0.76–1.94)

0.41

  

CA19-9 (500≦/<500 U/ml)

96/34

2.06 (1.15–3.69)

0.015*

1.70 (0.96–3.01)

0.07

Regional lymph node metastasis (+/−)

91/39

2.21 (1.17–4.19)

0.015*

2.24 (1.22–4.10)

0.009*

Tumour volume (≥6283, <6283 mm3)

71/59

3.60 (2.10–6.17)

<0.0001*

2.31 (1.68–5.52)

0.0002*

C5a-C5aR1 c-axis (High/Low)

48/82

1.89 (1.17–3.04)

0.009*

1.77 (1.02–3.07)

0.04*

C5a-C5aR2 c-axis (High/Low)

70/60

0.62 (0.39–1.00)

0.050

0.65 (0.91–2.57)

0.11

C5a-C5aR1 s-axis (High/Low)

51/79

2.22 (1.38–3.57)

0.001*

2.55 (1.51–4.30)

0.0005*

  1. Cox proportional hazard model, *: significant value.