Fig. 5: NETs upregulate anti-apoptotic proteins in PDAC cells. | British Journal of Cancer

Fig. 5: NETs upregulate anti-apoptotic proteins in PDAC cells.

From: Gemcitabine-induced neutrophil extracellular traps via interleukin-8-CXCR1/2 pathway promote chemoresistance in pancreatic cancer

Fig. 5

a, b Proteins were extracted from PDAC cells 72 h after treatment with each CM, and western blotting was performed. c Schematic representation of the hypothesis explored in this study. GEM-treated PDAC cells secreted inflammatory cytokines, that triggered chemoNETosis. NETs acted on PDAC cells to activate Erk1/2 signalling, upregulate Bcl-xL, thereby inducing chemoresistance.

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