Fig. 4 | Cancer Gene Therapy

Fig. 4

From: Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma

Fig. 4

Intratumor regulated IL-12 gene delivery by Ad-RTS-mIL-12+veledimex induces systemic immune memory in the GL-261 orthotopic mouse glioma model. Surviving animals that had been previously treated with Ad-RTS-mIL-12+veledimex 450 mg/m2/day were rechallenged with 1 × 105 GL-261 glioma cells at the same coordinates as the prior studies (N = 36). The control group consisted of 12 age-matched C57BL/6 mice (20–23 weeks old) inoculated with 1 × 105 GL-261 glioma cells and survival monitored for an additional 73 days. *P < 0.05 versus age-matched control

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