Fig. 6
From: Targeting GD2-positive glioblastoma by chimeric antigen receptor empowered mesenchymal progenitors
Bi-functional MSC-based targeting approach against GBM. Scheme representing the possible targeted killing mechanism by locally injected bi-functional MSCs co-expressing the truncated form of the anti-GD2 CAR (GD2 tCAR) and the membrane-bound TRAIL (mTRAIL). MSCs surface functionalization with GD2 tCAR could enforce the in vivo interaction with GD2-expressing GBM cells, allowing a selective target recognition in such a way to empower mTRAIL-mediated pro-apoptotic effect
