Fig. 7 | Cancer Gene Therapy

Fig. 7

From: LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p /ROCK1

Fig. 7

Reduction of SNHG14 level improved neuronal function in MCAO/R treated rats. The animals were injected with lentiviral particle containing sh SNHG14 or sh control into lateral ventricle and 2 weeks later subjected MCAO operation. a The effect of SNHG14 silencing on the focal ischemia of brain sections and quantitative analysis of brain infarct volumes was shown by TTC staining in MCAO/R rats. b The role of interference of SNHG14 on the neuronal impairment was assessed by neurological deficit scores. c, d The effect of decreased SNHG14 on the ROCK1 protein level in vivo was measured by IF and western blot. e Representative images of neuron cells in the hippocampus and cortex were acquired by HE staining in animals injected with TDNG14 lentiviral following MCAO/R. N = 6 per group. Data were expressed as mean ± SD. ***P < 0.001 represents statistically difference. Scale bar = 100 μm

Back to article page