Fig. 4
From: SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma
SGPL1 sequence analysis. a Nucleotide sequence alignment of the main coding SGPL1 transcript variant 1 between NCBI CDS (Reference Sequence: NM_003901.3) and non-tumorigenic HSkM cells compared to tumor cell lines RD, RH-30, HA-OH1, Ax-OH-1, and A-204. SGPL1 cDNA sequencing revealed a homozygous base exchange from Adenine to Guanine at position 321 in the sequence of the SGPL1 transcript in RH-30 and HA-OH1 RMA cells. b Schematically illustration generated with elements of https://smart.servier.com shows the putative effect of the homozygous point mutation in the N-terminal region of the SGPL1. The mutation might interfere with anchorage in the ER membrane resulting in cytoplasmic SGPL1 localization. All data and download files of Servier Medical Art by Servier are freely available at https://smart.servier.com and licensed under a ‘Creative Commons Attribution 3.0 Unported License’
