Fig. 7
GATA3-induced attenuation of p-STAT3 activation in ccRCC cells. The 769-P and ACHN cells were transfected with overexpression GATA3 plasmid or control vector for 48 h, and (a) the relative protein expressions of p-STAT3 and STAT3 were detected by western blotting. *P < 0.05 vs. vector. b 769-P/vector, 769-P/GATA3, and ACHN/vector ACHN/GATA3 were incubated with 200 μg/ml IL-6 for 48 h. The expression of p-STAT3 and STAT3 was detected by western blotting. *P < 0.05, **P < 0.001 vs. vector. The representative results from one of the three independent experiments are presented. Note that GATA3 inhibited the IL6-induced STAT3 activation
