Fig. 6: The model describing how EMT-like related machinery promotes OS dedifferentiation and enhanced metastatic potential. | Cancer Gene Therapy

Fig. 6: The model describing how EMT-like related machinery promotes OS dedifferentiation and enhanced metastatic potential.

From: Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma

Fig. 6

Metastatic cascade occurs within a small subset of primary tumor cells that acquire the ability to migrate, intravasate into the bloodstream, resist anoikis, and survive at distant tissue sites, like the lung. CTC circulating tumor cell, dCTC derived circulating tumor cell.

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