Fig. 8: Immunohistochemical analysis of xenograft tumors. | Cancer Gene Therapy

Fig. 8: Immunohistochemical analysis of xenograft tumors.

From: c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1

Fig. 8

Ki-67 staining corresponds to tumor volume with high staining in JNK2 KD clones. Ki-67 positivity score was counted in three sections per tumor and was displayed as means (±SD) of three sections: JNK WT: 8.2% pos., JNK1 KD: 6.6% pos., JKN2 KD: 53.5% pos. (first two lanes). Isoform KD was retained in vivo with reduced expression of either protein in the target clones compared to M-Neo-17. KD of either isoform reduced p–c-Jun levels in vivo (lanes 3–5).

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