Fig. 2: LOAd viruses replicate in multiple myeloma cells.
From: Immunostimulatory oncolytic virotherapy for multiple myeloma targeting 4-1BB and/or CD40
Human multiple myeloma cell lines (ANBL-6 (a), L363 (b), LP-1 (c), OPM-2 (d), RPMI-8226 (e), and U266-84 (f)) were infected with 50 MOI of LOAd viruses or replication-deficient Ad5/35 Mock virus. Viral DNA was isolated at 2, 24, 48, and 96 h post infection and quantified with primers detecting adenoviral DNA. Graphs display the fold change of viral DNA compared to baseline (2 h post infection). n = 2; technical replicates = 3; graphs show mean ± SEM.
