Fig. 9: Knockdown of long intergenic non-protein coding RNA 1291 (LINC01291) inhibits the chemoresistance of melanoma cells to cisplatin. | Cancer Gene Therapy

Fig. 9: Knockdown of long intergenic non-protein coding RNA 1291 (LINC01291) inhibits the chemoresistance of melanoma cells to cisplatin.

From: Long noncoding RNA LINC01291 promotes the aggressive properties of melanoma by functioning as a competing endogenous RNA for microRNA-625-5p and subsequently increasing IGF-1R expression

Fig. 9

A A-375 and HT-144 cells transfected with either si-LINC01291 or si-NC were incubated with cisplatin for 48 h. CCK-8 assay was performed to determine whether LINC01291 can affect the chemoresistance of A-375 and HT-144 cells to cisplatin. **P < 0.01 vs. group si-NC. B The LINC01291-silenced A-375 and HT-144 cells were transfected with anti-NC or anti-miR-625-5p. After incubation with cisplatin for 48 h, the CCK-8 assay was performed to determine the survival rate in different groups. **P < 0.01 vs. group “si-NC”. #P < 0.01 vs. group “si-LINC01291 + anti-miR-625-5p”. C A-375 and HT-144 cells were cotransfected with pc-IGF-1R or pcDNA3.1 and si-LINC01291. After incubation with cisplatin for 48 h, the CCK-8 assay was performed to determine the survival rate in different groups. **P < 0.01 vs. group “si-NC”. #P < 0.01 vs. group “si-LINC01291 + pcDNA3.1”.

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