Fig. 2: Combination therapy promoted apoptosis and necrosis in the TME. | Cancer Gene Therapy

Fig. 2: Combination therapy promoted apoptosis and necrosis in the TME.

From: Oncolytic adenoviruses synergistically enhance anti-PD-L1 and anti-CTLA-4 immunotherapy by modulating the tumour microenvironment in a 4T1 orthotopic mouse model

Fig. 2

A The tumour tissue was subjected to H&E staining to confirm necrosis. B The tumour tissue was also subjected to immunohistochemistry to detect caspase-3 expression, and representative images are shown (scale bars = 50 μm). C The percentage of caspase-3+ cells. The data are presented as mean ± SEM. **p < 0.01 versus control; ##p < 0.01 versus aPC. One-way ANOVA followed by Bonferroni post hoc tests was used.

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