Fig. 2: CXCR4 expression level in vitro and in liver metastases (murine model). | Cancer Gene Therapy

Fig. 2: CXCR4 expression level in vitro and in liver metastases (murine model).

From: Non-invasive detection and complementary diagnosis of liver metastases via chemokine receptor 4 imaging

Fig. 2

A Flow cytometry analysis of CXCR4 expression in UM cell lines. The CXCR4 expression of ten different UM cell lines were evaluated and the expression varied from 11.5% (OCM1) to 91% (M20-09-196). B BAP1 expression (red, top row) in UM: no nuclear BAP1 in M20-09-196 and M20-07-070 or nuclear BAP1 expression in 92.1 and positive control (human UM), CXCR4 expression presented in their hepatic metastases of UM mouse models and tonsil as a positive control (bottom). C CXCR4 expression was found in cytoplasm of liver metastases (right column) in UM mouse models generated by 92.1 (top), M20-07-070 (middle) and Mel290 (bottom), which expressed low, intermediate, and high levels of CXCR4 in vitro, respectively. Histology (left column) and gp100 (middle column) identified the formation of hepatic metastases from ocular melanoma. D Quantitative analysis showed high levels of CXCR4 expression in hepatic metastases in UM mouse models generated by eight types of human UM cell lines.

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