Fig. 6: MR images and histological correlation of hepatic metastases in mice models OMM2.3 and OCM1 with ProCA32.CXCR4 administration. | Cancer Gene Therapy

Fig. 6: MR images and histological correlation of hepatic metastases in mice models OMM2.3 and OCM1 with ProCA32.CXCR4 administration.

From: Non-invasive detection and complementary diagnosis of liver metastases via chemokine receptor 4 imaging

Fig. 6

A MR image of OMM2.3 mouse following the administration of ProCA32.CXCR4 (post-injection) shows the metastatic lesions in the liver. The metastasis in the MR image was identified in the H & E staining slide of the liver tissue from the same mouse. Immunofluorescent staining of the tumor tissue verified the expression of CXCR4 (green) and gp100 (yellow), CXCR4 and gp100 expressions are overlapped (merge). B Post-injection MR image of the OCM1 mouse exhibits the liver metastases that are invisible in the pre-injection MR image. Metastases in the H&E staining are well-correlated with the ones recognized in the MR image and show positive during CXCR4 and HMB45 immunohistochemistry staining. C The measurement of metastases (n = 45) in MR images correlates with the corresponding results in H&E staining, both in diameters (left, Y = 0.945 x−0.176, R2 = 0.885) and areas (right, Y = 0.934 x + 0.066, R2 = 0.882).

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