Fig. 1: TRAIP expression levels in TNBC tissues and cells. | Cancer Gene Therapy

Fig. 1: TRAIP expression levels in TNBC tissues and cells.

From: Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT

Fig. 1

A, B Comparison of TRAIP mRNA expression between normal tissue and primary tumor, and breast cancer subclasses. C Kaplan–Meier survival curves of 95 patients with high and low expression of TRAIP in TNBC. D TRAIP expressions were higher in TNBC than adjacent tissues at protein levels. T: tumor, A: adjacent tissue. E Immunohistochemistry showing TRAIP was higher in TNBC than in corresponding adjacent tissues. Moreover, the lymph node metastasis foci showed stronger TRAIP expression than the corresponding primary foci. Upper left: adjacent tissue, upper right: TNBC tissue, lower left: primary foci, lower right: lymph node metastasis foci. DAB (brown) served as chromogen. F The TRAIP protein levels in MCF-7, MDA-MB-231, MDA-MB-468 and BT-549 cells lines. G–I The silence and overexpression efficiency of TRAIP were detected by Western blot and β-actin were used as control. Data were expressed as the gray-scale ratio of TRAIP protein relative to that of β-actin. All data are shown as the means ± SD of three experiments. (***P < 0.001, **P < 0.01, *P < 0.05).

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