Fig. 6: TRAIP reverses the effects of miR-590-3p on cells migration and invasion through EMT. | Cancer Gene Therapy

Fig. 6: TRAIP reverses the effects of miR-590-3p on cells migration and invasion through EMT.

From: Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT

Fig. 6

A Wound healing assay was conducted to determine the effect between miR-590-3p and TRAIP on cell migration. B The migration and invasion of MDA-MB-231and BT-549 cells were showed by Transwell assays. C Western blot were performed to detect the expression of MMP-2, MMP-9, Twist, Slug, Vimentin, E-cadherin. All data are shown as the means ± SD of three experiments. MDA-MB-231 was transfected with miR-590 inhibitor, miR-590 inhibitor + ShTRAIP-1. BT-549 was transfected with miR-590 mimic, miR-590 mimic + OETRAIP. (**P < 0.01, *P < 0.05, Control vs. miR-590 inhibitor, or Control vs. miR-590 mimic; ##P < 0.01, #P < 0.05, miR-590 inhibitor vs. miR-590 inhibitor + ShTRAIP-1, or miR-590 mimic vs. miR-590 mimic+OETRAIP).

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