Fig. 4: NAP1L2 contributes to the migration, invasion and EMT process of PCa cells. | Cancer Gene Therapy

Fig. 4: NAP1L2 contributes to the migration, invasion and EMT process of PCa cells.

From: LncNAP1L6 activates MMP pathway by stabilizing the m6A-modified NAP1L2 to promote malignant progression in prostate cancer

Fig. 4

A RT-qPCR examine NAP1L2 expression in PCa cell lines (22RV1), PCa bone metastasis cell lines (PC3, C4-2B and VCaP) and PCa brain metastasis cell line (DU145). *P < 0.05, **P < 0.01. B NAP1L2 was knocked down in PC3 cells. C NAP1L2 was overexpressed in PC3 cells. D–G Cell migration was observed through wound healing assays when NAP1L2 was downregulated or upregulated. H, I Western blot analyzed the protein levels of ZO-1, E-cadherin, N-cadherin and Vimentin after NAP1L2 was silenced or overexpressed. **P < 0.01.

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