Fig. 4: Epigenomic profiling of histone PTMs changes induced by maltonis in NB4 cells. | Cancer Gene Therapy

Fig. 4: Epigenomic profiling of histone PTMs changes induced by maltonis in NB4 cells.

From: Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Fig. 4

H3K4me3, H3K9me3, and H3K27ac were investigated genome-wide by ChIP-seq in NB4 cells treated with 10 µM maltonis for 24 h or left untreated. Biological triplicates of each treated and untreated sample have been produced and analyzed. A PCA showing the clustering of the three fo histone PTMs investigated. B Pie charts showing the genomic annotation of DERs found to be enriched (UP) or depleted (DOWN) by maltonis treatment in each histone PTM investigated. The total number of differential enriched regions (DERs) is reported in blue, while upregulated and downregulated regions are indicated in green and red, respectively. C Volcano plot showing selected gene-associated DERs. Regions were considered differentially enriched if log2(FC) ≤ −0.58 or log2(FC) ≥ 0.58 and with an FDR ≤ 0.01. Upregulated DERs are shown in green while downregulated DERs are shown in red. The total number of DERs analyzed and the one found regulated are reported at the top of each graph.

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