Fig. 5: Genome-wide comparison between gene expression and epigenomic modulations in NB4 cells treated with maltonis. | Cancer Gene Therapy

Fig. 5: Genome-wide comparison between gene expression and epigenomic modulations in NB4 cells treated with maltonis.

From: Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Fig. 5

A Volcano plots showing the distribution of epigenetically modulated genes as compared with their differential expression status (DEGs) for each histone PTM investigated. DEGs that are not epigenetically modified are indicated in gray, while DEGs showing increased or decreased histone PTMs modulation are shown in green and red, respectively. The number of epigenetically upregulated and downregulated genes as compared with upregulated and downregulated DEGs is reported at the top of each graph. B GSEA of DEGs and genes with histone PTMs modulations. Hallmarks showing increased normalized enrichment score (NES) are indicated in green while the one with a negative NES are shown in red. Dimension of dots reflect FDR values as indicated in figure.

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