Fig. 6: C-MYC as a master regulator of maltonis-induced biological response in NB4 cells. | Cancer Gene Therapy

Fig. 6: C-MYC as a master regulator of maltonis-induced biological response in NB4 cells.

From: Small molecule-induced epigenomic reprogramming of APL blasts leading to antiviral-like response and c-MYC downregulation

Fig. 6

A Venn diagram of genes that contribute to the NES of the main downregulated hallmarks gene sets identified by GSEA. B Snapshots showing ChIP-seq and RNA-seq signals at MYC gene locus. Signals from untreated NB4 cells are indicated in black, while those from maltonis-treated cells are in lilac. RefSeq genes and CpG islands are shown in blue and green, respectively. C Evaluation of changes induced by maltonis to c-MYC protein abundance in NB4 cells. Cells were treated with the reported concentrations of maltonis and total cell lysates were analyzed by western blot. D Evaluation of changes induced by maltonis to c-MYC protein abundance in different hematopoietic tumor cell lines.

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