Fig. 6: An EMT network is associated with decreased survival probability in HNSCC. | Cancer Gene Therapy

Fig. 6: An EMT network is associated with decreased survival probability in HNSCC.

From: HPV status represents dominant trait driving delineation of survival-associated gene co-expression networks in head and neck cancer

Fig. 6

A Genes of the Pink_IS score (n = 124) and the Pink_DS score (n = 461) were analyzed for pathway enrichment. B Enrichment scores of ‘Myogenesis’ and ‘Epithelial Mesenchymal Transition’ (EMT) were calculated for each cell of a published HNSCC scRNAseq dataset [7] using the AUCell package. C, D Myogenesis (C) and EMT (D) gene set enrichment scores for each cell type were visualized as Violin plot (left). Heatmaps (right) show ranking of Myogenesis (C) and EMT (D) enriched cell types (gene enrichment scores above the threshold as determined by Mixtools package) and expression of pathway specific genes across cell types. E Pearson correlation analysis was performed between the proportion of T cells and the proportion of fibroblasts of the HNSCC scRNAseq data [7]. F Density plot depicts expression of NT5E (CD73) across cell types [7]. G Correlation between CAF_score and Cyan_IS score in TCGA-HNSCC.

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