Fig. 3: EVs from NLCs and M2-THP1 increase the expression of apoptosis-related proteins. | Cancer Gene Therapy

Fig. 3: EVs from NLCs and M2-THP1 increase the expression of apoptosis-related proteins.

From: Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo

Fig. 3

CLL-B-cells from 3 different patients (patients #4, 6 and 11 - supplementary table 1) were treated with EVs derived either from NLCs or M2-THP1 cells, after 24 h, cells were harvested and cell lysates were subjected to western blot analysis. A Immunoblot anti-IGFBP2, (B) Immunoblot anti-CD40 (C) Immunoblot anti-p53 and (D) an immunoblot anti-BCL2. Densitometric analyses are represented under blots. In all cases, the actin signal was used for normalization. Results were compared with a Kruskal-Wallis test and are presented as mean ± SD. Immunoblots presented are representative of three independent experiments.

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