Fig. 4: NLCs EVs induce gene expression changes in CLL-B-cells. | Cancer Gene Therapy

Fig. 4: NLCs EVs induce gene expression changes in CLL-B-cells.

From: Extracellular vesicles from type-2 macrophages increase the survival of chronic lymphocytic leukemia cells ex vivo

Fig. 4

A Principal component analysis (PCA) of RNAseq data transcripts of patients’ CLL-B-cells treated (“NLCs EVs”) or not (“Untreated”) with NLCs EVs. (Patients #10, 12 & 13- Supplementary Table 1). B Volcano plot showing differential expression of genes (DEG) with FDR < 0.05 in CLL-B-cells from patients treated with NLCs EVs. C Heatmap displaying the results of a hierarchical clustering of all differentially expressed genes between CLL-B-cells treated with NLCs EVs versus those untreated. D Differential expression of selected genes following NLCs EVs treatment of CLL-B-cells.

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