Fig. 4: Significant immune cell fractions in MSLN high CRC are found in B cells macrophages, neutrophils, NK cells, and T-regs regardless of patient cohort. | Cancer Gene Therapy

Fig. 4: Significant immune cell fractions in MSLN high CRC are found in B cells macrophages, neutrophils, NK cells, and T-regs regardless of patient cohort.

From: Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer

Fig. 4

RNA-seq using Quantiseq and subsequent deconvolution to estimate immune cell fraction (A) further characterized the tumor immune microenvironment. Immune-related gene expression (B) was analyzed in MSLN low and high CRC in the entire and MSS cohorts via WTS, where Chi-square and Mann–Whitney U tests were implemented for statistical analyses, with p values adjusted for multiple comparisons. *q < 0.05; **q < 0.01; ***q < 0.001.

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