Fig. 5: Microsatellite stable CRC with high MSLN exhibits significant gene enrichment for inflammation and immune response. | Cancer Gene Therapy

Fig. 5: Microsatellite stable CRC with high MSLN exhibits significant gene enrichment for inflammation and immune response.

From: Mesothelin expression correlates with elevated inhibitory immune activity in patients with colorectal cancer

Fig. 5

Gene set enrichment analysis (GSEA) was performed in MSLN low and high CRC entire cohort (A) and MSS cohort (B). Positive values for normalized enrichment score (NES) indicate enhanced pathway signaling for the indicated gene set. Where FDR ≤ 0.25 is considered significant between MSS and the entire cohort. Significantly different gene sets are indicated in red.

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