Fig. 6: The HOPE strategy reduced the stemness of cancer cells.
From: NF-κB-activated oncogene inhibition strategy for cancer gene therapy
A UMAP plot of subclusters derived from the HOPE-treated and non-treated samples. The subclusters are coloured according to cell type. B UMAP plot of cancer cell subclusters in the HOPE-treated and non-treated samples. The subclusters of cancer cells are represented by different colours. C Sankey diagram showing the proportions of the subclusters of cancer cells in the HOPE-treated and non-treated samples. D Pseudotime trajectories of the cancer cell subclusters. The differentiation direction was defined by the stemness score. The cancer cell subclusters are represented by different colours. E Comparison of stemness scores among the cancer cell subclusters. F The expression of oncogenes targeted by the HOPE strategy in HOPE-treated samples in the cancer cell subclusters. HOPE-treated, rAAV-HOPE-treated; non-treated, PBS-treated.
