Table 3 Pharmacokinetic parameters of S2172.

From: Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma

Cmax (µM)

1.20 ± 0.12

Tmax (hr)

0.25

T1/2 (hr)

4.98 ± 1.64

AUC0–6 h (µM·hr)

1.11 ± 0.08

Plasma concentration at 0.5 hr (µM)

0.75 ± 0.09

Brain concentration at 0.5 hr (µM)

1.52 ± 0.14

Brain/plasma ratio

2.06 ± 0.39

  1. Pharmacokinetic parameters were determined in 8-week-old Crl:CD1 (ICR) mice treated with a single intraperitoneal injection at 30 mg/kg (n = 3).
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