Table 1 Potential strategies and mechanisms of targeting ammonia-induced cell death in cancer immunotherapy.
From: Ammonia death: a novel potential strategy to augment immunotherapy in cancer
Strategy | Mechanism | Potential benefits | Clinical relevance |
|---|---|---|---|
Inhibiting ammonia accumulation | Blocking RHCG transport | Reducing lysosomal and mitochondrial damage | Prolonging T-cell lifespan |
Enhancing autophagy | Promoting clearance of damaged mitochondria | Rescuing T cells from ammonia-induced apoptosis | Enhancing T-cell-mediated tumor clearance |
Ammonia metabolism modulation | Targeting glutamine metabolism | Preventing excessive ammonia production | Increasing efficacy of adoptive T-cell therapies |
