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The role of tumor-derived exosomal LncRNA in tumor metastasis

Cancer Gene Therapy volume 32, pages 273–285 (2025)Cite this article

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A Correction to this article was published on 24 April 2025

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Abstract

Tumor metastasis regulated by multiple complicated pathways is closely related to variations in the tumor microenvironment (TME). Exosomes can regulate the TME through various mechanisms. Exosomes derived from tumor cells carry a variety of substances, including long non-coding RNAs (lncRNAs), play important roles in intercellular communication and act as critical determinants influencing tumor metastasis. In this review, we elaborate on several pivotal processes through which lncRNAs regulate tumor metastasis, including the regulation of epithelial‒mesenchymal transition, promotion of angiogenesis and lymphangiogenesis, enhancement of the stemness of tumor cells, and evasion of immune clearance. Additionally, we comprehensively summarized a diverse array of potential tumor-derived exosomal lncRNA biomarkers to facilitate accurate diagnosis and prognosis in a clinical setting.

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Fig. 1: The biogenesis of exosomes and lncRNAs.
Fig. 2: Tumor-derived exosomes have been demonstrated to promote the metastasis of cancer.

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Funding

This work was supported by the National Key R&D Program of China (2021YFE0202000), China-Bulgaria Science and Technology Cooperation Committee 18th Regular Meeting Exchange Project (18-9), the Affiliated Qingyuan Hospital of Guangzhou Medical University (202301-301), The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University (20240068JJ), Guangzhou Medical University Undergraduates project (pdjh 2022b0425, 02-410-2206301).

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Author notes

  1. These authors contributed equally: Zhile Yu, Jiali Fu, Vanya Mantareva, Ivica Blažević.

Authors and Affiliations

  1. The Fifth Affiliated Hospital, Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular Target & Clinical Pharmacology, The NMPA and State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 510700, PR China

    Zhile Yu, Jiali Fu, Yusong Wu, Dianchang Wen, Yuqing Wang & Jianye Zhang

  2. Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Bld. 9, 1113, Sofia, Bulgaria

    Vanya Mantareva

  3. Department of Organic Chemistry, Faculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000, Split, Croatia

    Ivica Blažević

  4. School of Pharmacy, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia

    Tungalag Battulga

  5. The Affiliated Traditional Chinese Medicine Hospital, Guangzhou Medical University, Guangzhou, 510140, PR China

    Yuqing Wang

  6. The Affiliated Qingyuan Hospital, Guangzhou Medical University, Qingyuan, 511518, PR China

    Jianye Zhang

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Contributions

Zhile Yu, Jiali Fu and Yusong Wu: wrote the manuscript; Tungalag Battulga, Dianchang Wen: completed the figures and tables; Vanya Mantareva, Ivica Blažević: revised the manuscript; Yuqing Wang, Jianye Zhang: conceived and revised the manuscript; All authors have read and approved the final manuscript.

Corresponding authors

Correspondence to Tungalag Battulga, Yuqing Wang or Jianye Zhang.

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Yu, Z., Fu, J., Mantareva, V. et al. The role of tumor-derived exosomal LncRNA in tumor metastasis. Cancer Gene Ther 32, 273–285 (2025). https://doi.org/10.1038/s41417-024-00852-x

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