Fig. 1: Inverse correlation of Tob expression level and NF-κB activity level in breast cancer cell lines. | Cancer Gene Therapy

Fig. 1: Inverse correlation of Tob expression level and NF-κB activity level in breast cancer cell lines.

From: Tob negatively regulates NF-κB activation in breast cancer through its association with the TNF receptor complex

Fig. 1

Correlation between Tob (a) or Tob2 (b) expression and NF-κB activity level in 35 breast cancer cell lines. Red dots show basal-like subtypes, blue dots show luminal subtypes, and white dot showed not determined (N.D.). Tob and Tob2 expression was from Microarray data [23]. NF-κB activity level was calculated by EMSA in previous reports [6]. r: Pearson’s correlation coefficient. p: p-values. p-values were calculated from t-test (t-value = -3.97 (a), = 0.288 (b)). c Western blotting of Tob in each cell lines. d mRNA expression level of Tob were measured using real-time RT-PCR. mRNA expression levels were normalized by Gapdh. Induction levels were calculated by dividing each Tob expression level by that of MCF-7. These results indicate the mean ± S.D. (n = 3).

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