Fig. 2: Expression of immunoregulatory lncRNAs in glioma-infiltrating immune cells. | Cancer Gene Therapy

Fig. 2: Expression of immunoregulatory lncRNAs in glioma-infiltrating immune cells.

From: Identification of an immunomodulatory lncRNA signature associated with immune cell reprogramming in high-grade glioma

Fig. 2

Bubble plots showing the proportion and expression levels of specific lncRNAs in: (A) pro-inflammatory myeloid cells, B immunosuppressive myeloid cells, and (C) T and NK cells. A–C RCAS-PDGFb transcriptome analyzed by scRNAseq. D Spatial distribution of immunoregulatory lncRNAs by laser microdissection of immune cell populations in the TME of 41 GBM patients. E Scatterplots showing the correlation between specific lncRNAs and immune infiltration levels in GBM patients. Each plot includes a fitted regression line (), partial correlation coefficients (), and p-values. F Kaplan-Meier survival curves comparing the survival of glioblastoma multiforme (GBM) patients with high (red, n = 39) versus low (blue, n = 113) expression of the lncRNA SNHG6, evaluated from the TGCA database (log-rank test, p = 0.03). G Illustration summarizing the main findings of the study (biorender.com).

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