Table 1 Summary of lncRNAs and their roles in the TIME of HGG RCAS models.

From: Identification of an immunomodulatory lncRNA signature associated with immune cell reprogramming in high-grade glioma

lncRNA

PDGFb

BRAF V600E

Cell localization

Role in cancer immune cells

Reference

 

(Fc)

(Fc)

  

(PMID)

Meg3

36.27

0.04

nuclear and cytoplasmic

Negative correlation with infiltrating lymphocytes B, T (CD8+, CD4 + ), and myeloid cells (macrophages, neutrophils, dendritic cells) infiltration in low-grade gliomas.

34220951

MIAT

78.48

 

nuclear and cytoplasmic

Upregulated in Tregs, PDCD1 + CD8+ and GZMK + CD8 + T cells.

33221703

Mir9-3hg

11.44

 

nuclear

Promotes M2 polarization, and G-MDSC recruitment

32910548

38145323

Malat1

1.64

2.16

nuclear

Promotes infiltration of MDSCs, TAMs, and inhibitory activity on effector T cells

37603945

34295338

37637063

Ftx

3.9

 

nuclear

Negative correlation with infiltrating CD8+ T-cells

32419983

36359790

SNHG20

1.52

1.69

cytoplasmic

Promotes M2 polarization and cellular reprogramming

34970275

35506150

SNHG12

0.38

1.78

cytoplasmic

Promotes M2 polarization

32927431

37006268

35658874

SNHG6

0.42

 

cytoplasmic

Negative correlation with infiltration of Neutrophils, DCs and macrophages

37006268

34734036

34794493

Pvt1

0.65

2.39

cytoplasmic

Overexpressed in MDSCs, promotes infiltration of G-MDSCs

30925926

31404149

Trp53Cor1

0.29

0.38

nuclear

Tumor suppressor regulated by p53 pathway, reverses M2 polarization

32062693

(lincRNA-p21)

H19

0.21

 

nuclear and cytoplasmic

Positive correlation with infiltrating CD4 + T, CD8 + T, B, DCs, neutrophils and macrophages

35810257

37637063

Neat1

0.14

5.01

nuclear

Promotes inflammatory response, infiltration of M1-macrophage, influences the TIME. Regulates infiltration and antitumor activity of cytotoxic T cells, and controls M2 macrophage polarization.

37053197

31731055

Mir17hg

0.15

1.81

nuclear

Prevent Tregs differentiation

21972292

29499238

Mir142hg

0.11

2.54

nuclear

Controls differentiation and function of lymphocytes T, B, and myeloid cells (macrophages and dendritic cells)

38201290

23809164

  1. Expression levels, cellular localization, and roles of specific immunoregulatory lncRNAs in the tumor immune microenvironment (TIME) of RCAS-PDGFb (“cold” TIME) and RCAS-BRAF V600E (“hot” TIME) HGG models. Expression in RCAS HGG models is reported as fold change (Fc) relative to immune cells isolated from the brains of age-matched, no-tumor control mice. The roles of each lncRNA in cancer-related immune cells are summarized from the literature. References (PMID) are provided for each lncRNA.
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