Fig. 4: APC germline mutations and the secondary protein structure of the FAP-hESC lines.
From: Predicting colorectal cancer risk in FAP patients using patient-specific organoids
A Description of the type and location of APC germline mutations in each of the three FAP-hESC lines and their effect on the protein sequence. RYI – (R-Arginine, Y-Tyrosine, I-Isoleucine); LVISLE – (L-Leucine, V-Valine, I-Isoleucine, S-Serine, L-Leucine, E-Glutamine acid). B Model of the secondary protein structure of the full APC protein and the truncated forms of FAP1, FAP2 and FAP3. The AlphaFold2 model based on dLDDT of the APC full domain and the truncated forms of FAP1, FAP2 and FAP3. Model confidante is indicated in a color scale ranging from very low in orange to very high in blue. C The APC- FAP3, FAP1 and FAP2 model is showcased, delineating the various domains: APC is highlighted in gray, FAP1 in green and purple, FAP3 in green, and FAP2 in a combination of green, purple, and pink.
