Fig. 7: mTOR pathway genes expression in the colon of FAP1 patient.
From: Rapamycin rescues APC-mutated colon organoid differentiation
A H&E staining of normal and cancerous colon biopsies from FAP1 patient. B Representative immunohistochemical staining of p-mTOR (C) p-mTOR expression quantification utilized the open-source image analysis software Ilastik. D, E Representative immunohistochemical downstream protein p-eIF4E in normal and cancerous FAP1 patient biopsies. White arrows indicate regions of high mTOR pathway gene expression. Healthy colon tissue served as a control. X4 Scale bars- 500 µm, X10 Scale bars- 200 µm, X20 Scale bars- 100 µm, X40 Scale bars- 50 µm.
