Fig. 2: Sensitivity of OVCA cell line panel to platinum-based chemotherapies and resistance-associated gene expression signatures of HGSOC.
A Cisplatin and (B) carboplatin IC50 values for 33 OVCA cell lines of various subtypes. Line and error bars for each subtype show the mean +/- standard error of the mean. Colors of points indicate what is known about patient (Pt) pre-treatment with platinum-based chemotherapy prior to derivation of the cell line, where red indicates the Pt received platinum prior to tumor acquisition, blue indicates Pt did not receive platinum, and gray indicates that treatment is unknown. Cmax range is shown with the yellow rectangle. C Volcano plot and (D) heatmap showing differentially expressed genes between HGSOC cell lines based on platinum sensitive, intermediate, and resistant classifications from our data in (A, B). Genes with demonstrated roles in platinum-resistance in the literature are labeled in the volcano plot. Values in the heatmap for each gene are centered on the mean of the transformed expression across the eleven cell lines, and the red dotted line indicates p = 0.05.
