Fig. 1: PH potentiates the growth inhibition of 5FU and Oxaliplatin in PDAC cells. | Cancer Gene Therapy

Fig. 1: PH potentiates the growth inhibition of 5FU and Oxaliplatin in PDAC cells.

From: Paricalcitol and hydroxychloroquine modulates extracellular matrix and enhance chemotherapy efficacy in pancreatic cancer

Fig. 1

A–C The indicated cancer cell lines were treated with various concentration of 5FU (15 μM) and Oxaliplatin (25 μM), paricalcitol (350 nM), and hydroxychloroquine (25 μM) for 3 days and subjected to MTT assays. Relative percentage cell viability was plotted with respect to DMSO treated cells. D The indicated cancer cell lines were treated with DMSO, PH, 5FU+oxali, and combination (PH + 5FU+Oxali) for 2–4 weeks, and long-term cell survival was measured using clonogenic assays. Representative images are shown. E Colony counts from the clonogenic assay data shown in (D). Data represent the mean ± standard error of three biological replicates. Statistical significance was assessed using two-way ANOVA. ns not significant, *p < 0.05, ****p < 0.0001.

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