Fig. 4: The addition of PH to 5FU and Oxaliplatin alters protein expression profiles in PDAC, influencing key pathways including ECM signaling, DNA repair, and apoptosis. | Cancer Gene Therapy

Fig. 4: The addition of PH to 5FU and Oxaliplatin alters protein expression profiles in PDAC, influencing key pathways including ECM signaling, DNA repair, and apoptosis.

From: Paricalcitol and hydroxychloroquine modulates extracellular matrix and enhance chemotherapy efficacy in pancreatic cancer

Fig. 4

A cluster heat map of proteomic profiles through four experimental conditions is shown, with each row representing a different protein and each column corresponding to a sample group. The heat map displays differential protein expression levels, where regions in red indicate increased expression and blue regions indicate decreased expression. White areas indicate no change in expression. The conditions shown are DMSO, PH, 5FU + Oxali, and PH + 5FU + Oxali. A Cluster heat map of ECM signaling profile. B Cluster heat map of Collagen formation profile. C Cluster heat map of ECM proteoglycans profile. D Cluster heat map of integrin signaling profile. E Cluster heat map of cell-cell communications profile. F Cluster heat map of integrin cell surface interactions profile. G Cluster heat map of DNA repair profile. H Cluster heat map of chromatin organization profile. I Cluster heat map of apoptosis profile. J Cluster heat map of programmed cell death profile.

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