Fig. 3

BOK promotes chemical-induced hepatocarcinogenesis. a Gross liver tumor morphology and corresponding representative H&E-stained tumors in WT and Bok^-/- animals 9 months after DEN treatment (25 mg/kg BW). b Quantification of liver tumors in WT and Bok^-/- animals. Values represent the mean ± SD (WT n = 10; Bok^-/- n = 13). c Average tumor size per group (diameter by caliper). d Quantification of histologically confirmed HCC. Values represent the mean ± SD (n = 10 per group; blindly evaluated and randomly selected). e H&E-stained sections of livers 9 months after DEN injection. Histopathological examination revealed that Bok^-/- animals are less prone to inflammation, ballooning, and steatohepatitis and f show less steatosis in non-tumor areas. Values represent the mean ± SD (n = 10 per group; blindly evaluated and randomly selected)