Fig. 7: Evaluation of mitophagy control by p53 in mice brain.
From: Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation
LC3-2/LC3-1 (a, N = 9), p62 (b N = 9), TIM23 (c, N = 9) and optineurin (OPTN, d, N = 9) protein levels were analyzed in control (p53+/+) or TP53-deficient (p53−/−) knockout mice brains as described in the Methods. Bars represent the means ± SEM of 3 independent experiments performed in triplicate and are expressed as percent of control (p53+/+) cells. Actin expression is provided as a representative gel loading control in a. Statistical analyses were performed with GraphPad Prism software by using unpaired Student’s t-test. Significant differences are: ** p < 0.01, ***p < 0.001.
